As Investigators they were not seen interacting much except for a recollection where Sasaki questioned Hirako about who Arima truly was as a person.

When Kaneki defects from the CCG and forms Goat, Tsukiyama joins him at his side as his best friend and right-hand man. He realized that both of them tried to help and protect others just because they both did not want to be alone. Touka is one of the closest people to Kaneki in Anteiku, helping him adapt to ghoul life. He would often provide Kaneki with information regarding the ghoul world and assists in his development. She then gave Kaneki a ring engraved with her parents' names, citing it as something she holds dear, which he happily accepted before declaring that they should move to meet up with the rest of Goat.Touka was visited by Nishiki while she supervised the children in Goat's care following the organization's relocation to the 24th ward. He is still aware that Tsukiyama wishes to eat him even if he tries to hide it, but Kaneki never shows concern for his own safety, trusting that his strength will intimidate Tsukiyama and keep him in check. Elsewhere Touka sat bandaged and resting from the wounds she received when she stopped Kaneki's rampage.When Kaneki just started working part-time at Anteiku, his friend Hide came to give him a visit. Even during the Goat Extermination Operation, Kaneki and Juuzou display no hate towards each other, only fighting as a result of knowing what needs to be done. After being held captive and undergoing intense torture at the hands of Yamori, Kaneki's personality changed drastically. He does however, not want him to continue having it once things have settled. He does however, show Sasaki a little bit of acknowledgement as a leader, even stating Sasaki is a better leader than his own boss. He still had his old habit of scratching or rubbing his chin whenever he was hiding something or lying from his days as Kaneki. Following the Clown Siege, during another private talk, she asked about this and his virginity — causing him some obvious nervousness and discomfort. After Shimoguchi lost his squad however, Sasaki was quick to offer condolences to the man. However, he was still troubled with the fact that he was a half-ghoul and wanted to search for a place where he could belong. Within his mind, he encounters a child version of himself that he feels the desire to protect. As these memories came back to him, the child expressed that Kaneki was trying to die during the events at V14. She is aware and interested in his half-human nature as she had few or no interactions with human society. They continue to fight, with Touka telling him to stop being such a pain before Mutsuki blocks her kagune attacks using his knives. “But I dunno if it’ll even be born right. He viewed this action as abandoning him, choosing his aunt rather than himself. While Kaneki doesn't regret meeting Rize as he's met many friends along the way, "Rize" states that she hates him as she'd never be reduced to her current state if she'd never met Kaneki at Anteiku. I’m sorry.”Naturally, Ken freaks out over the response, but his first action is one which no one saw coming; The hero asks to marry Touka in a roundabout way. Shimoguchi however, did not hesitate to humiliate Sasaki when he got the chance. She is willing to kill for her, shown when a group of human boys attempted to take her, Touka was seconds from killing them in public, despite the risks of her ghoul nature being discovered by the surrounding crowd. However, upon releasing his new Kagune, his body appears to have returned to normal, with his hands once again possessing five fingers and being without the previous scales. This more innocent Kaneki accepts him and thanks him for all that he has done to protect them. When Kaneki heard that the CCG was going to attack Anteiku he immediately decided to go despite the overwhelming number of CCG forces. She immediately turned to block Upon reaching Route E14, Touka and the ghouls stopped when they encountered a large squad of Oggai.